AAV with CamKII promoter driven mCitrine

This AAV expresses mCitrine driven by a neuron CamKII promoter.

This 1.3 Kb promoter is derived from the murine α-Calcium/calmodulin-dependent kinase II (CaMKII), a gene with expression restricted to excitatory neurons in the neocortex and hippocampus. In cortical neurons, it was shown that the promoter activity of CaMKII(1.3) is about double that of CaMKII(2.4), probably due to some inhibitory element(s).

mCitrine, like Venus, is derived from YFP, with increased brightness and stability. mCitrine has an Excitation/Emission spectrum of 516nm/529nm which is almost identical to that of EYFP, Venus and Topaz.