AAV with CamKII(0.4) promoter driven hChR2(E123T/H134R)-EGFP

Category: AAV > Over-Expression > Optogenetics
Cat. No: VB3512
Availability: 2-3 weeks
Name: AAV-CamKII(0.4)-hChR2(E123T/H134R)-EGFP
This AAV expresses hChR2(E123T/H134R)-EGFP driven by a neuron CamKII(0.4) promoter.

This 0.4 Kb promoter is derived from murine α-Calcium/calmodulin-dependent kinase II (CaMKII), a gene with expression restricted to excitatory neurons in the neocortex and hippocampus. It was shown that the promoter activity of CaMKII(0.4) is almost identical to that of CaMKII(1.3) in cortical neurons, Compared to CaMKII(1.3), this short promoter allows cloning of longer gene of interest into the AAV construct .

hChR2(E123T/H134R), also known as ChETA, is a channelrhodopsin-2 variant with faster deactivation kinetics.

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Viral Details

Viral Backbone
Recombinant AAV
AAV-ITR
AAV2
AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter
CamKII(0.4) (neuron)
Storage Buffer
PBS/5% Glycerol
Volume
200ul
Titer
1x10^13 GC/ml

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