mouse MELK shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-280882
Availability:
3-5 weeks
Name:
Ad-m-MELK-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Melk.
Request a Quote
Please enter your email address and we'll be in touch with more information:
Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Melk
- Gene Name
- maternal embryonic leucine zipper kinase
- Gene ID
- 17279
- Gene Synonyms
- AI327312; mKIAA0175; MPK38
- ORF Size
- 1932 bp
- RefSeq#
- NM_010790
- Gene Description
- Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
- UniGene ID
- Mm.268668
Related Products
Product | Cat No. |
---|---|
AAV-h-MELK | AAV-215293 |
AAV-m-MELK | AAV-280882 |
Ad-h-MELK | ADV-215293 |
Ad-m-MELK | ADV-280882 |
AAV-h-MELK-shRNA | shAAV-215293 |
AAV-m-MELK-shRNA | shAAV-280882 |
Ad-h-MELK-shRNA | shADV-215293 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
Vector Biolabs
293 Great Valley Parkway
Malvern, PA 19355
Email: info@vectorbiolabs.com
Phone: +1 484-325-5100
Toll-free (US Only): 877-BIO-LABS
Fax: +1 215-525-1112
Privacy Policy