mouse MASTL shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-280876
Availability:
5-8 weeks
Name:
Ad-m-MASTL-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Mastl.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Mastl
- Gene Name
- microtubule associated serine/threonine kinase-like
- Gene ID
- 67121
- Gene Synonyms
- 2700091H24Rik; C88295; GW; GWL; MAST-L; THC2
- ORF Size
- 2598 bp
- RefSeq#
- NM_025979
- Gene Description
- Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
- UniGene ID
- Mm.253721
Related Products
Product | Cat No. |
---|---|
AAV-h-MASTL | AAV-215061 |
AAV-m-MASTL | AAV-280876 |
Ad-h-MASTL | ADV-215061 |
Ad-m-MASTL | ADV-280876 |
AAV-h-MASTL-shRNA | shAAV-215061 |
AAV-m-MASTL-shRNA | shAAV-280876 |
Ad-h-MASTL-shRNA | shADV-215061 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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