mouse TOP1MT shRNA silencing Adenovirus

Cat. No: shADV-274815

Availability: 3-5 weeks

Name: Ad-m-TOP1MT-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Top1mt.

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Species: Mouse
Gene Symbol: Top1mt
Gene Name: DNA topoisomerase 1, mitochondrial
Gene ID: 72960
Gene Synonyms: 2900052H09Rik
ORF Size: 1779 bp
RefSeq#: NM_028404
Gene Description: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
UniGene ID: Mm.182401