mouse SMARCD3 shRNA silencing Adenovirus

Cat. No: shADV-272620

Availability: Immediate

Name: Ad-m-SMARCD3-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Smarcd3.

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Species: Mouse
Gene Symbol: Smarcd3
Gene Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Gene ID: 66993
Gene Synonyms: 1500001J14Rik; 2210409C08Rik; BAF60C
ORF Size: 1452 bp
RefSeq#: NM_025891
Gene Description: Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
UniGene ID: Mm.436539