mouse RNF20 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-270723
Availability:
3-5 weeks
Name:
Ad-m-RNF20-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Rnf20.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Rnf20
- Gene Name
- ring finger protein 20
- Gene ID
- 109331
- Gene Synonyms
- 4833430L21Rik; AW540162; C79397; mKIAA4116
- ORF Size
- 2922 bp
- RefSeq#
- NM_182999
- Gene Description
- Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator.
- UniGene ID
- Mm.24765
Related Products
Product | Cat No. |
---|---|
AAV-h-RNF20 | AAV-221398 |
AAV-m-RNF20 | AAV-270723 |
Ad-h-RNF20 | ADV-221398 |
Ad-m-RNF20 | ADV-270723 |
AAV-h-RNF20-shRNA | shAAV-221398 |
AAV-m-RNF20-shRNA | shAAV-270723 |
Ad-h-RNF20-shRNA | shADV-221398 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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