mouse RET shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-270410
Availability:
5-8 weeks
Name:
Ad-m-RET-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Ret.
Request a Quote
Please enter your email address and we'll be in touch with more information:
Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Ret
- Gene Name
- ret proto-oncogene
- Gene ID
- 19713
- Gene Synonyms
- c-Ret; PTC; RET51; RET9
- ORF Size
- 3222 bp
- RefSeq#
- NM_009050
- Gene Description
- Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Act as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
- UniGene ID
- Mm.57199
Related Products
Product | Cat No. |
---|---|
AAV-h-RET | AAV-221016 |
AAV-m-RET | AAV-270410 |
Ad-h-RET | ADV-221016 |
Ad-m-RET | ADV-270410 |
AAV-h-RET-shRNA | shAAV-221016 |
AAV-m-RET-shRNA | shAAV-270410 |
Ad-h-RET-shRNA | shADV-221016 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
Vector Biolabs
293 Great Valley Parkway
Malvern, PA 19355
Email: info@vectorbiolabs.com
Phone: +1 484-325-5100
Toll-free (US Only): 877-BIO-LABS
Fax: +1 215-525-1112
Privacy Policy