mouse RAD21 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-270054
Availability:
3-5 weeks
Name:
Ad-m-RAD21-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Rad21.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Rad21
- Gene Name
- RAD21 cohesin complex component
- Gene ID
- 19357
- Gene Synonyms
- mKIAA0078; SCC1
- ORF Size
- 1908 bp
- RefSeq#
- NM_009009
- Gene Description
- Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
- UniGene ID
- Mm.470496
Related Products
Product | Cat No. |
---|---|
AAV-h-RAD21 | AAV-220636 |
AAV-m-RAD21 | AAV-270054 |
Ad-h-RAD21 | ADV-220636 |
Ad-m-RAD21 | ADV-270054 |
AAV-h-RAD21-shRNA | shAAV-220636 |
AAV-m-RAD21-shRNA | shAAV-270054 |
Ad-h-RAD21-shRNA | shADV-220636 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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