mouse IL1R2 shRNA silencing Adenovirus

Cat. No: shADV-262139

Availability: 5-8 weeks

Name: Ad-m-IL1R2-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Il1r2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Species: Mouse
Gene Symbol: Il1r2
Gene Name: interleukin 1 receptor, type II
Gene ID: 16178
Gene Synonyms: CD121b; Il1r-2
ORF Size: 843 bp
RefSeq#: NM_010555
Gene Description: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
UniGene ID: Mm.1349