mouse FOXO1 shRNA silencing Adenovirus

Product Info

Knockdown

>60% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Foxo1

Gene Name

forkhead box O1

Gene ID

56458

Gene Synonyms

Afxh; AI876417; FKHR; Fkhr1; Foxo1a

ORF Size

1956 bp

RefSeq#

NM_019739

Gene Description

Transcription factor which acts as a regulator of cell responses to oxidative stress. In the presence of KIRT1, mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence (By similarity). Triggers death of postmitotic neurons when phosphorylated by CDK1. Activates transcription of PMAIP1.

UniGene ID

Mm.29891