mouse DYRK2 shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Dyrk2

Gene Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Gene ID

69181

Gene Synonyms

1810038L18Rik

ORF Size

1800 bp

RefSeq#

NM_001014390

Gene Description

Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. Phosphorylates CRMP4/DPYSL3, EIF2B5, GYS1, p53/TP53, TAU/MAPT, STAT3 and KATNA1. Regulates p53/TP53 by phosphorylation on 'Ser-46' to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of its downstream substrate, KATNA1. Phosphorylation of CRMP4/DPYSL3 promotes its subsequent phosphorylation by GSK3.

UniGene ID

Mm.458174