mouse CCND2 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-254861
Availability:
Immediate
Name:
Ad-m-CCND2-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Ccnd2.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Ccnd2
- Gene Name
- cyclin D2
- Gene ID
- 12444
- Gene Synonyms
- 2600016F06Rik; AI256817; BF642806; C86853; cD2; Vin-1; Vin1
- ORF Size
- 870 bp
- RefSeq#
- NM_009829
- Gene Description
- Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
- UniGene ID
- Mm.333406
Product Citations
This product is referenced in the following publications:
Related Products
Product | Cat No. |
---|---|
AAV-h-CCND2 | AAV-204491 |
AAV-m-CCND2 | AAV-254861 |
Ad-h-CCND2 | ADV-204491 |
Ad-m-CCND2 | ADV-254861 |
AAV-h-CCND2-shRNA | shAAV-204491 |
AAV-m-CCND2-shRNA | shAAV-254861 |
Ad-h-CCND2-shRNA | shADV-204491 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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