mouse CBFA2T2 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Cbfa2t2

Gene Name

core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)

Gene ID

12396

Gene Synonyms

A430091M07; C330013D05Rik; Cbfa2t2h; MTGR1

ORF Size

1785 bp

RefSeq#

NM_172860

Gene Description

CBFA2T2 may function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.

UniGene ID

Mm.29914