mouse CATSPER3 shRNA silencing Adenovirus

Cat. No: shADV-254582

Availability: 5-8 weeks

Name: Ad-m-CATSPER3-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Catsper3.

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Species: Mouse
Gene Symbol: Catsper3
Gene Name: cation channel, sperm associated 3
Gene ID: 76856
Gene Synonyms: 4921522D01Rik; CACRC
ORF Size: 1023 bp
RefSeq#: NM_029772
Gene Description: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
UniGene ID: Mm.159795