mouse CASP8 shRNA silencing Adenovirus

Cat. No: shADV-254562

Availability: 3-5 weeks

Name: Ad-m-CASP8-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Casp8.

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Species: Mouse
Gene Symbol: Casp8
Gene Name: caspase 8
Gene ID: 12370
Gene Synonyms: CASP-8; FLICE; MACH; Mch5
ORF Size: 1443 bp
RefSeq#: NM_009812
Gene Description: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp- -AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
UniGene ID: Mm.336851