mouse ITM2B shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Itm2b

Gene Name

integral membrane protein 2B

Gene ID

16432

Gene Synonyms

AI256040; Bri; Bri2; Bricd2b; D14Sel6; E25BMM; imBRI2

ORF Size

801 bp

RefSeq#

NM_008410

Gene Description

Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites|Function: Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42|Function: Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.

UniGene ID

Mm.4266