mouse ADAR shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-252106
Availability:
3-5 weeks
Name:
Ad-m-ADAR-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Adar.
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Product Info
- Knockdown
- >80% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Adar
- Gene Name
- adenosine deaminase, RNA-specific
- Gene ID
- 56417
- Gene Synonyms
- Adar1; Adar1p110; Adar1p150; AV242451; mZaADAR
- ORF Size
- 3459 bp
- RefSeq#
- NM_019655
- Gene Description
- Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
- UniGene ID
- Mm.316628
Related Products
Product | Cat No. |
---|---|
AAV-m-ADAR | AAV-252106 |
Ad-h-ADAR | ADV-200406 |
Ad-m-ADAR | ADV-252106 |
AAV-h-ADAR-shRNA | shAAV-200406 |
AAV-m-ADAR-shRNA | shAAV-252106 |
Ad-h-ADAR-shRNA | shADV-200406 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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