mouse ACO1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Aco1

Gene Name

aconitase 1

Gene ID

11428

Gene Synonyms

Aco-1; Irebp; Irp1

ORF Size

2670 bp

RefSeq#

NM_007386

Gene Description

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding|Function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).

UniGene ID

Mm.331547