human CTC1 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

CTC1

Gene Name

CST telomere replication complex component 1

Gene ID

80169

Gene Synonyms

AAF-132; AAF132; C17orf68; CRMCC; tmp494178

ORF Size

3654 bp

RefSeq#

NM_025099

Gene Description

CTC1 encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants.

UniGene ID

Hs.156055

HGNC ID

HGNC:26169