human TNNI1 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-226129
Availability:
5-8 weeks
Name:
Ad-h-TNNI1-shRNA
This is an Adenovirus expressing shRNA for silencing of Human TNNI1.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- TNNI1
- Gene Name
- troponin I1, slow skeletal type
- Gene ID
- 7135
- Gene Synonyms
- SSTNI; TNN1
- ORF Size
- 564 bp
- RefSeq#
- NM_003281
- Gene Description
- Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
- UniGene ID
- Hs.320890
- HGNC ID
- HGNC:11945
Related Products
Product | Cat No. |
---|---|
AAV-h-TNNI1 | AAV-226129 |
AAV-m-TNNI1 | AAV-253445 |
Ad-h-TNNI1 | ADV-226129 |
Ad-m-TNNI1 | ADV-253445 |
AAV-h-TNNI1-shRNA | shAAV-226129 |
AAV-m-TNNI1-shRNA | shAAV-253445 |
Ad-m-TNNI1-shRNA | shADV-253445 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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