human TMED10 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

TMED10

Gene Name

transmembrane p24 trafficking protein 10

Gene ID

10972

Gene Synonyms

p23; P24(DELTA); p24d1; S31I125; S31III125; Tmp-21-I; TMP21

ORF Size

660 bp

RefSeq#

NM_006827

Gene Description

TMED10 is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. TMED10 has a pseudogene on chromosome 8.

UniGene ID

Hs.74137

HGNC ID

HGNC:16998