human TINF2 shRNA silencing Adenovirus

Product Info

Knockdown

>50% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

TINF2

Gene Name

TERF1 interacting nuclear factor 2

Gene ID

26277

Gene Synonyms

DKCA3; TIN2

ORF Size

1356 bp

RefSeq#

NM_012461

Gene Description

TINF2 encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.

UniGene ID

Hs.496191

HGNC ID

HGNC:11824