human TDO2 shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

TDO2

Gene Name

tryptophan 2,3-dioxygenase

Gene ID

6999

Gene Synonyms

TDO; TO; TPH2; TRPO

ORF Size

1221 bp

RefSeq#

NM_005651

Gene Description

TDO2 encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

UniGene ID

Hs.183671

HGNC ID

HGNC:11708