human TCOF1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

TCOF1

Gene Name

treacle ribosome biogenesis factor 1

Gene ID

6949

Gene Synonyms

MFD1; TCS; TCS1; treacle

ORF Size

2877 bp

RefSeq#

NM_000356

Gene Description

TCOF1 encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.605019

HGNC ID

HGNC:11654