human SPG11 shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SPG11

Gene Name

spastic paraplegia 11 (autosomal recessive)

Gene ID

80208

Gene Synonyms

ALS5; CMT2X; KIAA1840

ORF Size

6993 bp

RefSeq#

NM_025137

Gene Description

SPG11 is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.683876

HGNC ID

HGNC:11226