human SDHD shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SDHD

Gene Name

succinate dehydrogenase complex subunit D

Gene ID

6392

Gene Synonyms

CBT1; CII-4; CWS3; cybS; PGL; PGL1; QPs3; SDH4

ORF Size

480 bp

RefSeq#

NM_003002

Gene Description

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The subunit D protein is one of two integral membrane proteins anchoring the complex to the matrix side of the membrane. Mutations in SDHD have been linked to hereditary paraganglioma.

UniGene ID

Hs.356270

HGNC ID

HGNC:10683