human SCRIB shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SCRIB

Gene Name

scribbled planar cell polarity protein

Gene ID

23513

Gene Synonyms

CRIB1; SCRB1; SCRIB1; Vartul

ORF Size

4965 bp

RefSeq#

NM_015356

Gene Description

SCRIB encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

UniGene ID

Hs.436329

HGNC ID

HGNC:30377