human SAT1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SAT1

Gene Name

spermidine/spermine N1-acetyltransferase 1

Gene ID

6303

Gene Synonyms

DC21; KFSD; KFSDX; SAT; SSAT; SSAT-1

ORF Size

516 bp

RefSeq#

NM_002970

Gene Description

SAT1 belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.

UniGene ID

Hs.28491

HGNC ID

HGNC:10540