human SARDH shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SARDH

Gene Name

sarcosine dehydrogenase

Gene ID

1757

Gene Synonyms

BPR-2; DMGDHL1; SAR; SARD; SDH

ORF Size

2757 bp

RefSeq#

NM_007101

Gene Description

SARDH encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described.

UniGene ID

Hs.198003

HGNC ID

HGNC:10536