human RP2 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

RP2

Gene Name

retinitis pigmentosa 2 (X-linked recessive)

Gene ID

6102

Gene Synonyms

DELXp11.3; NM23-H10; NME10; TBCCD2; XRP2

ORF Size

1053 bp

RefSeq#

NM_006915

Gene Description

The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death

UniGene ID

Hs.44766

HGNC ID

HGNC:10274