human RAD21 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

RAD21

Gene Name

RAD21 cohesin complex component

Gene ID

5885

Gene Synonyms

CDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1

ORF Size

1896 bp

RefSeq#

NM_006265

Gene Description

RAD21 is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

UniGene ID

Hs.81848

HGNC ID

HGNC:9811