human PTPN13 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-220310
Availability:
3-5 weeks
Name:
Ad-h-PTPN13-shRNA
This is an Adenovirus expressing shRNA for silencing of Human PTPN13.
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Product Info
- Knockdown
- >70% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- PTPN13
- Gene Name
- protein tyrosine phosphatase, non-receptor type 13
- Gene ID
- 5783
- Gene Synonyms
- FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE
- ORF Size
- 7401 bp
- RefSeq#
- NM_006264
- Gene Description
- PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
- UniGene ID
- Hs.436142
- HGNC ID
- HGNC:9646
Related Products
Product | Cat No. |
---|---|
Ad-h-PTPN13 | ADV-220310 |
Ad-m-PTPN13 | ADV-269795 |
Ad-m-PTPN13 | ADV-269796 |
AAV-h-PTPN13-shRNA | shAAV-220310 |
AAV-m-PTPN13-shRNA | shAAV-269795 |
Ad-m-PTPN13-shRNA | shADV-269795 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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