human PKD2 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PKD2

Gene Name

polycystin 2, transient receptor potential cation channel

Gene ID

5311

Gene Synonyms

APKD2; Pc-2; PC2; PKD4; TRPP2

ORF Size

2907 bp

RefSeq#

NM_000297

Gene Description

PKD2 encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.

UniGene ID

Hs.181272

HGNC ID

HGNC:9009