human PDE1C shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PDE1C

Gene Name

phosphodiesterase 1C

Gene ID

5137

Gene Synonyms

cam-PDE 1C; hCam-3; Hcam3

ORF Size

1905 bp

RefSeq#

NM_005020

Gene Description

Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 (PubMed 1326532)).(supplied by OMIM, Oct 2009)

UniGene ID

Hs.655694

HGNC ID

HGNC:8776