human PCSK9 shRNA silencing Adenovirus

Product Info

Knockdown

shRNA screening service available, please inquire about this service or other options.

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PCSK9

Gene Name

proprotein convertase subtilisin/kexin type 9

Gene ID

255738

Gene Synonyms

FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9

ORF Size

2079 bp

RefSeq#

NM_174936

Gene Description

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

UniGene ID

Hs.18844

HGNC ID

HGNC:20001