human PANK1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PANK1

Gene Name

pantothenate kinase 1

Gene ID

53354

Gene Synonyms

PANK

ORF Size

1797 bp

RefSeq#

NM_138316

Gene Description

PANK1 encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. PANK1 and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636).

UniGene ID

Hs.715502

HGNC ID

HGNC:8598