human ORC2L shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-217925
Availability:
5-8 weeks
Name:
Ad-h-ORC2L-shRNA
This is an Adenovirus expressing shRNA for silencing of Human ORC2.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ORC2
- Gene Name
- origin recognition complex subunit 2
- Gene ID
- 4999
- Gene Synonyms
- ORC2L
- ORF Size
- 1734 bp
- RefSeq#
- NM_006190
- Gene Description
- The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
- UniGene ID
- Hs.444870
- HGNC ID
- HGNC:8488
Related Products
Product | Cat No. |
---|---|
AAV-h-ORC2L | AAV-217925 |
AAV-m-ORC2L | AAV-267688 |
Ad-h-ORC2L | ADV-217925 |
Ad-m-ORC2L | ADV-267688 |
AAV-h-ORC2L-shRNA | shAAV-217925 |
AAV-m-ORC2L-shRNA | shAAV-267688 |
Ad-m-ORC2L-shRNA | shADV-267688 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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