human NSUN2 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

NSUN2

Gene Name

NOP2/Sun RNA methyltransferase family member 2

Gene ID

54888

Gene Synonyms

MISU; MRT5; SAKI; TRM4

ORF Size

2304 bp

RefSeq#

NM_017755

Gene Description

NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

UniGene ID

Hs.481526

HGNC ID

HGNC:25994