human NOB1 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

NOB1

Gene Name

NIN1/PSMD8 binding protein 1 homolog

Gene ID

28987

Gene Synonyms

ART-4; MST158; MSTP158; NOB1P; PSMD8BP1

ORF Size

1239 bp

RefSeq#

NM_014062

Gene Description

In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 (PubMed 19706509)).(supplied by OMIM, Nov 2010)

UniGene ID

Hs.271695

HGNC ID

HGNC:29540