human MTAP shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

MTAP

Gene Name

methylthioadenosine phosphorylase

Gene ID

4507

Gene Synonyms

BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP

ORF Size

729 bp

RefSeq#

NM_002451

Gene Description

MTAP encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

UniGene ID

Hs.193268

HGNC ID

HGNC:7413