human MET shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

MET

Gene Name

MET proto-oncogene, receptor tyrosine kinase

Gene ID

4233

Gene Synonyms

AUTS9; c-Met; DFNB97; HGFR; RCCP2

ORF Size

4173 bp

RefSeq#

NM_000245

Gene Description

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.132966

HGNC ID

HGNC:7029