human MAP3K7IP1 shRNA silencing Adenovirus

Cat. No: shADV-214939

Availability: 3-5 weeks

Name: Ad-h-MAP3K7IP1-shRNA

This is an Adenovirus expressing shRNA for silencing of Human TAB1.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Species: Human
Gene Symbol: TAB1
Gene Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Gene ID: 10454
Gene Synonyms: 3'-Tab1; MAP3K7IP1
ORF Size: 1515 bp
RefSeq#: NM_006116
Gene Description: TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniGene ID: Hs.507681
HGNC ID: HGNC:18157