human MAP2K6 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

MAP2K6

Gene Name

mitogen-activated protein kinase kinase 6

Gene ID

5608

Gene Synonyms

MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3

ORF Size

1005 bp

RefSeq#

NM_002758

Gene Description

MAP2K6 encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

UniGene ID

Hs.463978

HGNC ID

HGNC:6846