human COX11 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-214138
Availability:
3-5 weeks
Name:
Ad-h-COX11-shRNA
This is an Adenovirus expressing shRNA for silencing of Human COX11.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- COX11
- Gene Name
- COX11, cytochrome c oxidase copper chaperone
- Gene ID
- 1353
- Gene Synonyms
- COX11P
- ORF Size
- 831 bp
- RefSeq#
- NM_004375
- Gene Description
- Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.
- UniGene ID
- Hs.591171
- HGNC ID
- HGNC:2261
Related Products
Product | Cat No. |
---|---|
AAV-h-COX11 | AAV-214138 |
AAV-m-COX11 | AAV-255964 |
Ad-h-COX11 | ADV-214138 |
Ad-m-COX11 | ADV-255964 |
AAV-h-COX11-shRNA | shAAV-214138 |
AAV-m-COX11-shRNA | shAAV-255964 |
Ad-m-COX11-shRNA | shADV-255964 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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