human LIG4 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-213923
Availability:
3-5 weeks
Name:
Ad-h-LIG4-shRNA
This is an Adenovirus expressing shRNA for silencing of Human LIG4.
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Product Info
- Knockdown
- >70% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- LIG4
- Gene Name
- DNA ligase 4
- Gene ID
- 3981
- Gene Synonyms
- LIG4S
- ORF Size
- 2736 bp
- RefSeq#
- NM_002312
- Gene Description
- LIG4 is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
- UniGene ID
- Hs.166091
- HGNC ID
- HGNC:6601
Related Products
Product | Cat No. |
---|---|
AAV-h-LIG4 | AAV-213923 |
AAV-m-LIG4 | AAV-263448 |
Ad-h-LIG4 | ADV-213923 |
Ad-m-LIG4 | ADV-263448 |
AAV-h-LIG4-shRNA | shAAV-213923 |
AAV-m-LIG4-shRNA | shAAV-263448 |
Ad-m-LIG4-shRNA | shADV-263448 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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