human JAK3 shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

JAK3

Gene Name

Janus kinase 3

Gene ID

3718

Gene Synonyms

JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK

ORF Size

1860 bp

RefSeq#

NM_000215

Gene Description

JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

UniGene ID

Hs.515247

HGNC ID

HGNC:6193