human JAK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human JAK2.
shADV-212573
Ad-h-JAK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human JAK2 (Janus kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK10; THCYT3; tyrosine-protein kinase JAK2
Description (eCommerce)
JAK2 (Janus kinase 2) was originally cloned via screening of mouse cDNA libraries with PCR generated probes representing highly conserved elements in the protein tyrosine kinase (PTK) family. JAK2, as well as JAK, was named after the Roman god, Janus, the god of gates or doors, and who is depicted as having two faces which face opposite directions. JAK kinases bear two nearly identical phosphate transferring domains and function to transduce signals from type I and type II cytokine receptors for the activation of STAT (signal transducers and activators of transcription) transcription factors.
Description (Vector)
JAK2 product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Gene ID
3717
Gene Name (eCommerce)
Janus kinase 2
Gene Name (Vector)
Janus kinase 2
Gene Symbol
JAK2
HGNC ID
HGNC:6192
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3390
ORF Size (bp)
3390 bp
Protein Name (eCommerce)
Tyrosine-protein kinase JAK2
RefSeq ID
NM_004972
RefSeq Synonyms
NM_004972, NM_001322204, NM_001322199, NM_001322198, NM_001322196, NM_001322195, NM_001322194, BC039695,
Research Areas
Apoptosis,BDNF Signaling,Cancer,Cardiology,Cardiovascular,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EPO Signaling,Histone Modification,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Lung Cancer,Neurobiology,Notch Signaling,PDGF Signaling,PI3K/Akt Signaling,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,TPO Signaling,TSH Signaling,TSLP Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
JAK2 (Janus kinase 2) was originally cloned via screening of mouse cDNA libraries with PCR generated probes representing highly conserved elements in the protein tyrosine kinase (PTK) family. JAK2, as well as JAK, was named after the Roman god, Janus, the god of gates or doors, and who is depicted as having two faces which face opposite directions. JAK kinases bear two nearly identical phosphate transferring domains and function to transduce signals from type I and type II cytokine receptors for the activation of STAT (signal transducers and activators of transcription) transcription factors.
UniGene ID
Hs.656213
UniProt ID (eCommerce)
O60674
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.