human IRAK4 shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

IRAK4

Gene Name

interleukin 1 receptor associated kinase 4

Gene ID

51135

Gene Synonyms

IPD1; IRAK-4; NY-REN-64; REN64

ORF Size

1383 bp

RefSeq#

NM_016123

Gene Description

IRAK4 encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

UniGene ID

Hs.138499

HGNC ID

HGNC:17967