human GCLC shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-209745
Availability:
3-5 weeks
Name:
Ad-h-GCLC-shRNA
This is an Adenovirus expressing shRNA for silencing of Human GCLC.
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Product Info
- Knockdown
- >80% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- GCLC
- Gene Name
- glutamate-cysteine ligase catalytic subunit
- Gene ID
- 2729
- Gene Synonyms
- GCL; GCS; GLCL; GLCLC
- ORF Size
- 1914 bp
- RefSeq#
- NM_001498
- Gene Description
- Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
- UniGene ID
- Hs.654465
- HGNC ID
- HGNC:4311
Related Products
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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